b'UNIVERSITY/PROJECT TITLE PROJECT SUMMARY RESEARCHCOLLABORATOR/SINSTITUTIONValidation of the Oxi- Oxi-Tech have developed the ozone producingUniversity ofOxi-TechCell Ozone Systemtechnology Oxi-Cell to combat bacterial biofilms.Southampton Solutionsfor the elimination ofOxi-Cell is fitted in-line to water systems to inhibit biofilms microbial growth. To validate this technology and facilitate the commercial uptake of Oxi-Cell, we will quantify the antimicrobial effects of this system on planktonic and biofilm populations. Plasma for theChronic wounds are costly to treat and significantlyUniversity ofFourth State prevention andaffect a patients quality of life. Bacterial biofilmsHull Medicinemanagement of chronic(specific bacterial structures) play an important role wound biofilms in chronic wounds, and are responsible for many antibiotic treatment failures. This project will test an exciting new technology to remove wound biofilms and promote healing.Development of aThis project will develop a novel non-thermal plasmaUniversity ofCreo Medical non-thermal plasmaapplicator system for the decontamination of medicalthe West ofLtd and Pentax applicator for theendoscopes during re-processing within hospitalEngland (UWE),Medicaldecontamination offacilities. This addresses the current clinical andBristolmedical endoscopes economic need to ensure that endoscope devices are free from the risk of cross contamination and potential infection for patients.Standardised complexBiofilms are rarely found comprised of one singleUniversity ofBluTest wound biofilm modelstype of microorganism, yet the development of newGlasgow Laboratories- a robust antimicrobialantimicrobials tends to focus on testing one bacteria. screening tool This project aims to develop methods and testing platforms that will allow industry partners to develop an effective anti-biofilm compounds using a platform representative of wounds.Rapid early andTo feasibility test an optical-fluorescence-basedLoughboroughSmith+Nephew accurate diagnosis detection technique that seeks to quantitativelyUniversity Ltdof wounds detect bacterial biofilms in infected wounds against a complex background of normal flora, and determine antibiotic susceptibility. The rapid single-step test, implementable at the bedside, can potentially transform wound care through improved clinical outcome and reduced costs.Commercialisation ofBiofilm formation in burn wounds is associatedUniversity ofPerfectusa burn wound biofilmwith treatment failure, poor clinical outcomes, andBath Biomed Ltdmodel to provide a newdevelopment of chronic non-healing wounds. This service for pre-clinicalproject will develop a UKAS-accredited pre-clinical research and testing inmodel of burn wound infection, that can support academia and industry both early-stage and commercial development of new products to control biofilm formation in wounds.53'