b'UNIVERSITY/PROJECT TITLE PROJECT SUMMARY RESEARCHCOLLABORATOR/SINSTITUTIONBioinspired proteinBiofilm formation on indwelling medical devices, such asUniversity ofVirustatictechnology for biofilmventilators or catheters, contributes significantly to theLiverpoolprevention on indwellingchronicity of infections, posing a substantial healthcare medical devices and economic burden. This project will investigate incorporation of natural protein-based technology to indwelling medical devices, and its effectiveness against biofilm formation. Accelerating innovationWe should design water-treatment biofilms like weNewcastleVeolia Water by designing waterdesign Formula 1 racing cars: in a high-performanceUniversity Technologies treatment biofilm media computer. From models of individual bacteria,and in silico incorporating realistic chemical and mechanicalNorthumbrian properties, we will show we can design a new generationWater Ltdof treatment biofilm media in silico. Development of novelThis project aims to develop novel biomimeticNewcastleTeleflex Medical biomimetic surfaces toantibiofilm surfaces for catheters without usingUniversity Europe Ltd and prevent biofilm formationantibiotics or other antimicrobial agents. This wouldUniversity of on catheters address catheter associated biofilm infections with theSouthampton aim of improving development of anti-fouling surfaces to prevent biofilm formation in the long-term.Development of anBacterial vaginosis (BV) affects women aged 15-44yrsUniversity ofVirustaticelectrospun antimicrobialbut is difficult to treat during menstruation. This projectBradfordcoated tampon forwill engineer a tampon with unique additional layers management of bacterialcontaining a smart antimicrobial protein that is released vaginosis during use to manage the bacteria that cause disruption to the normal biofilm of the vagina causing BV.Rapid easy-to-use andA point-of-care wound diagnostic test under developmentLoughboroughSmith+Nephew affordable diagnostics forwill be validated for rapid quantitative detection ofUniversity Ltd, Birmingham wound - 2 bacterial load and antimicrobial sensitivity using clinicalCity University, isolates of a range of wound relevant bacterial strains andLancaster wound samples. Successful validation will be progressedUniversity and towards further optimization and clinical trial supportedCromerix Ltdby an external grant.58'